Giant cell tumor of bone is a rare bone tumor that occurs mostly in long tubular bone. Although the tumor is benign, it shows infiltrative growth. Surgical resection is the main treatment modality, while embolization and radiotherapy can be used for tumors that cannot be surgically removed. Intracranial giant cell tumors of bone occur mainly in the bones of the skull base, such as the temporal bone, rock bone, and occipital bone, but are extremely rare. When the lesion is located at the base of the skull, it is difficult to be completely resected. We have carried out the treatment of skull base bone giant cell tumor with radio-wave knife combined with zoledronic acid and obtained good results. First, we present a case of a rapidly growing giant cell tumor of bone. One month after the patient’s giant cell tumor of bone surgery, the tumor rapidly increased in size. We developed a combination treatment plan of radiofrequency knife combined with zoledronic acid for the patient, and 3 months after the treatment, the tumor shrank significantly and the patient’s headache symptoms disappeared. Vision was not affected in any way. The following is the MRI film of tumor recurrence 1 month after the surgery Residual tumor recurrence after surgery, before the radio wave knife treatment. The image below is the image of the patient’s repeat head MRI The image above is the image of the repeat MRI 3 months after the radio wave knife treatment, the tumor shrunk by 70% and the patient returned to normal Treatment experience summary: We treated 6 patients with giant cell tumor of bone, 1 patient had two radio wave knife treatments and the tumor was well controlled. After that, we started to combine radio wave knife with zoledronic acid to treat giant cell tumor of bone, and got extremely good treatment results. This is the second patient we have treated with the combination, and we have obtained a surprisingly good result. I would like to make this advanced treatment option available to more patients through.