High urinary microalbumin in diabetes mellitus can be cured by timely treatment, shorter duration of the disease, and milder condition of some patients. Elevated urine microalbumin level in diabetic patients usually suggests that the patient has combined diabetic nephropathy. It is commonly seen in patients with type 1 diabetes, but also in patients with type 2 diabetes who have poor long-term glycemic control. According to the blood glucose level and renal function, we should choose appropriate hypoglycemic drugs to control blood glucose and slow down the development of diabetic nephropathy. It can also be treated with antihypertensive drugs and microvascular protective drugs to reduce urinary protein and delay the progression of proteinuria. After active treatment, some patients with mild renal lesions can have their urinary microalbumin reduced to normal; if persistent proteinuria occurs, it can only control and slow down the progress of the disease, but cannot be cured. It is recommended that diabetic patients with high urinary microalbumin seek medical treatment in time.