Moles are mostly pigmented, and there is no most effective way to get rid of them. According to the patient’s condition, we need to choose the appropriate treatment program, commonly used surgical treatment, physical therapy and other ways of treatment. 1. Surgical treatment: nevus is a benign skin tumor, usually does not need treatment, easy to grow in the palm and plantar, waist, armpit, groin and other easy to friction or injury parts of the nevus, you can take surgical excision treatment, and after the operation of histopathological examination. If the nevus is large or in a special location, joint skin flap transplantation may be needed. 2. Physical therapy: For smaller nevus cell nevus that does not occur in a location that is prone to friction, laser therapy can be used to remove the pigment particles. Generally, pigmented nevus does not need to be treated. If it affects the aesthetics or has color change, larger area or abnormal sensation in a short period of time, it suggests the possibility of malignant transformation, so it is recommended that patients go to regular hospitals in time to choose appropriate treatment according to their own situation and under the guidance of professional physicians.