The causes of diarrhea mainly include infectious diarrhea and non-infectious diarrhea, among which the most common pathogens of infectious diarrhea are rotavirus and enteric adenovirus, followed by Escherichia coli, Campylobacter, Salmonella, Shigella dysenteriae, Mycobacterium tuberculosis, etc. The treatment principle of diarrhea is to actively maintain the water-electrolyte balance, treat the cause symptomatically, use painkillers and antidiarrheal drugs carefully, and use drugs to regulate intestinal flora and protect the gastric mucosa if necessary. Norfloxacin is a quinolone antibacterial drug with broad-spectrum antibacterial effect, which is effective against most of the Enterobacteriaceae bacteria. Norfloxacin can treat infectious diarrhea caused by some sensitive Enterobacteriaceae bacteria, such as Escherichia coli and Bacillus dysenteriae; however, because of the abuse of quinolones in recent years, non-professionals have used norfloxacin to treat patients with viral or non-infectious diarrhea, resulting in a high rate of drug resistance, so the efficacy may be poor. Therefore, norfloxacin can only treat diarrhea caused by some bacterial infections, and is not effective for diarrhea caused by viruses, non-infectious factors, etc. And the use of the process needs to be used regularly, the course of treatment to be sufficient, the dose should be enough, not arbitrarily stop using, follow the doctor’s instructions.