Brucellosis is an infectious disease caused by Brucella infection, and treatment requires early medication and a full dose and course of combined antibiotics to achieve better results. First-line therapeutic drugs, such as doxycycline combined with rifampin, or doxycycline combined with streptomycin, are generally used. Doxycycline is a tetracycline derivative with high lipid solubility, which can enter the infected cells and bind to Brucella ribosomes to inhibit protein synthesis to inhibit the role of bacteria, but children under eight years old are prohibited. Generally Brucella infection in human body, mainly in macrophages and liver and spleen lymph nodes and other parts, clearing the infection is more difficult, the longer the antibiotic use, the more can reduce the probability of recurrence of brucellosis and treatment failure, six weeks of antibiotic course is the most basic treatment plan.