Itching in the perianal area should first be considered whether it is related to the patient’s inadequate local hygiene and cleanliness, and may also be related to physiological factors such as hotter weather, tighter underwear, clothing friction, more sweating, and consumption of spicy and stimulating foods. If it can be relieved in a short period of time without other accompanying symptoms, it is only necessary to ensure local comfort, cleanliness and dryness without special treatment. In addition, if patients are allergic to underwear or food, they may have perianal allergic reactions, including itching around the anus, which may be accompanied by papules and blisters. It is more likely to occur in sensitive people and can usually be treated with antihistamines, such as loratadine, cetirizine, benadryl, etc. If the effect is pathological, the disease can be treated by the following: 1. Anal pruritus: improper diet, poor hygiene habits, and systemic diseases may lead to the disease. The clinical manifestation is perianal pruritus discomfort, which may cause local chafing, bleeding and pain after scratching. It can usually be treated with topical glycolic lotion, application of lidocaine cream, etc. Oral antihistamines such as cetirizine and loratadine can also be taken. It can also be treated by traditional Chinese medicine such as gentian combination, alum dispersion, etc.; 2, perianal eczema: perianal eczema typically manifests as perianal itching, but also red papules, pus oozing and other symptoms. Usually related to the local often subject to friction, personal constitution, work environment, excrement stimulation and other influencing factors. It can be treated by using boric acid solution wet compresses, tacrolimus ointment, etc. When local fever, pain and other infection symptoms appear, you can choose suitable antibiotic treatment under the guidance of a doctor, such as cephalosporins, penicillin drugs, etc.; 3, anal fistula: usually related to poor prognosis after anal surgery, but also may be related to long-term constipation or diarrhea and other factors, can be manifested as a fistula mouth discharge and other symptoms. Usually you can choose surgery for treatment, but also according to the patient’s situation to choose drugs for auxiliary treatment, etc.; 4, femoral moss: commonly caused by infection of Trichophyton rubrum, such as living in a humid environment, or poor living habits, immune system is more common in people, can be manifested as erythema of the buttocks, the edge of the papule, can spread to the perianal skin caused by obvious itching. Treatment is based on topical drugs, such as imidazole, acrylamides, etc. Oral antifungal drugs, such as terbinafine and itraconazole, can be taken at the same time to remove pathogenic bacteria and further relieve symptoms. In addition, if there is a parasitic infection, such as pinworm disease can also cause perianal itching, with symptoms appearing mainly at night, and requires the application of anthelmintic treatment, such as albendazole. The symptoms of perianal itching may also be related to other factors, such as perianal scabies, neurodermatitis, hemorrhoids, diabetes, hyperthyroidism, and condyloma acuminata infection, due to the individual differences of patients. You should actively go to the hospital for consultation and targeted treatment. In daily life, attention should be paid to maintaining perianal hygiene and cleanliness, soft and comfortable underwear, a light diet, avoiding spicy and stimulating foods, and good bowel habits to avoid complications.