Pruritus in the anal folds is caused by a variety of causes with perianal skin stubborn itching as the main symptom, and the signs are often manifested as thickening of the perianal skin, hypertrophy of the folds, and mossy skin and pigmentation after a long period of illness. Topical medications are commonly used clinically and are generally divided into Western and Chinese medicines. A, topical western ointment 1, glucocorticosteroids: clinically common hydrocortisone cream, dexamethasone ointment, beclomethasone camphor ointment, tretinoin econazole cream, etc. These drugs have a strong anti-inflammatory effect, but also a certain immunosuppressive effect and anti-allergic effect, for eczema, dermatitis, pruritus patients. When the affected skin is combined with infection, it is appropriate to take oral anti-infective drugs at the same time; 2, antihistamines: antihistamines have anti-inflammatory, anti-itch and anti-allergic effects, such as Benadryl ointment, can be used for anal itching caused by allergies; 3, other: such as compound keratanate cream, can be used for hemorrhoids and other anal disorders caused by pain, itching, congestion and a small amount of bleeding. Second, topical Chinese ointments commonly used clinically dehumidification and antipruritic ointment, skin hemorrhoids Qing, BaiBu tincture, HuaTuo cream, dandruff ointment and other drugs, with insecticidal and anti-pruritic effect, for pruritus, lice disease, pubic itch and other patients, take the appropriate amount of drugs can be applied to the affected area, allergic to this product and skin breaks are prohibited. Third, other patients with itching in the anal folds, in addition to the use of ointment, can also carry out local rinsing or oral medication, common rinsing drugs such as glycolite lotion, Chuanbei anti-itch lotion, etc., common oral medication such as levocetirizine hydrochloride, moistening and anti-itch capsules, etc., can effectively relieve patients of itching symptoms. If the patient’s symptoms are not relieved for a long time after the above treatment, it is recommended to go to the hospital for treatment.