It is possible that the anus is very itchy with worms, such as pinworm disease. However, there are many causes of anal itching, such as perianal eczema, warts, hemorrhoids, anal fissures, and anal fistulas, etc. The presence of parasitic infections needs to be determined by stool routine. If it is a parasitic infection, commonly known as pinworms, which irritate the anus around the anus and cause itching, you can usually see small white worms around the anus with the naked eye, and its treatment is based on oral deworming medication. If the itching is not relieved after deworming treatment, or even continues to worsen, it may be due to other causes. If there is perianal eczema, you can use antihistamines to stop the itching, or you can apply localized glycomet lotion or glucocorticoid ointment; if there are hemorrhoids, you can apply hemorrhoid cream and other drugs, and if necessary, you can have surgery; if it is caused by warts, you need to go to the dermatology department for a clear diagnosis, and laser treatment or cryotherapy is generally feasible. If the patient has anal itching, the first thing to do is to identify the cause of anal itching and then take targeted treatment. In addition, you need to pay attention to keep your anus clean and dry, and change your underwear regularly.