The vast majority of patients with prostatitis have normal semen quality, only severe prostatitis can lead to seminal vesicles and epididymitis, and the quality of sperm in this case may be affected to some extent. The sperm are mainly produced in the testicles, mature gradually in the epididymis, and are stored in the seminal vesicles through the vas deferens. The high quality of sperm is related to prostatitis because part of the ejaculated sperm is prostatic fluid, and inflammation within the prostatic fluid can lead to a lower chance of sperm conception in the female vagina. The two most important factors that affect sperm quality are radiation and varicocele, especially varicocele can lead to impaired blood return and increased carbon dioxide accumulation, causing an increase in the concentration of prostaglandins and cortisol, resulting in abnormal sperm quality.