Patients with pulmonary hypertension are more painful once they progress to the advanced stage, because the main symptom of pulmonary hypertension patients in the advanced stage is recurrent dyspnea, which may occur even during rest at home. Therefore, the patient cannot leave the ventilator and carries it every day, which can lead to a very serious state of anxiety. Anxiety itself may also aggravate the severity of pulmonary hypertension, and patients may also have cyanosis, dyspnea, and syncope, such as suddenly falling to the ground upon waking up. Therefore, for patients with recurrent syncope and pulmonary hypertension, it is generally recommended that bedridden patients should get up gently and not suddenly or squatting patients should not suddenly stand up. Patients may also have hemoptysis, and patients with pulmonary hypertension may face rupture of small pulmonary arteries after advanced stage. Pulmonary artery rupture may lead to hemoptysis, and patients with recurrent hemoptysis and recurrent infections may be treated with a series of sputum removal and nebulization. Patients may be hospitalized repeatedly because of heart failure, kidney failure, and swelling, which not only increases the burden on the family, but also may increase the financial burden, so patients in advanced stages feel more painful. For patients with advanced pulmonary hypertension, a positive attitude must be encouraged to face it. During hospitalization, active medication including sputum drainage, infection prevention, oxygenation and targeted drug therapy can be given to slow down the progress of the disease and reduce the patient’s pain as much as possible.