Cyanosis is a manifestation of increased reduced hemoglobin in the blood that causes cyanotic changes in the skin and mucous membranes, which may also be referred to as cyanosis. In cyanosis, the onset is characterized by cold sensation and cyanosis at the extremities of the limbs. It is mostly seen in young women. What is the etiology of limb cyanosis? Skin changes occur in areas with a thick subcutaneous fat layer and in areas exposed to cold due to fashion. Endocrine dysfunction also plays a role. It occurs most often in girls and young women who wear short skirts or are obese, and is more frequent in cold areas and seasons. Peripheral cyanosis: due to impaired blood flow in the peripheral circulation. It is seen in body circulation stasis, inadequate perfusion of peripheral tissues, and local blood circulation disorders, such as right heart failure, massive pericardial effusion, and cold stimulation in severe shock. The clinical characteristics of cyanosis are that it often appears at the end of the limb and the drooping part, such as the end of the limb, earlobe, nose tip, etc. The skin of the cyanotic area is cold, and if it is warmed up or massaged to make it warm, the cyanosis can be reduced or disappeared. How to diagnose cyanosis of extremities? The lesion often involves both hands and manifests itself at the ends of the extremities. Persistent, uniform cyanosis may appear on the entire hand and wrist or even the back, cold, and exposure to cold air may aggravate the symptoms, but warm environment often fails to reduce or disappear it, accompanied by swollen fingers, stiff feeling, and sweaty palms. No ulceration or gangrene formation was observed.