Pulmonary blisters in the lower lobe of the right lung are most often detected by CT examination of the chest and may not have any clinical manifestations. They are seen in patients with long-term smoking, bronchial asthma, chronic obstructive pulmonary disease, chronic pulmonary fibrosis, and previous history of old tuberculosis. Some patients with family genetic factors are more likely to form pneumoconiosis. Once a pulmonary blister has formed, the decision to surgically remove it is based on the size of the blister and its impact on lung function. Pulmonary blisters themselves do not disappear, therefore, CT findings of pulmonary blister formation require dynamic follow-up. If a patient develops cough, coughing sputum or sudden dyspnea, he/she should be alerted to the formation of pneumothorax due to rupture of pulmonary blisters and needs to be given a chest X-ray as soon as possible to find out whether pneumothorax is formed. Once a pneumothorax occurs it needs to be hospitalized as soon as possible and thoracentesis aspiration is given to restore the function of the lung tissue. In conclusion, if a pneumothorax is formed in the lower lobe of the right lung, the size of the pneumothorax and whether it is accompanied by clinical symptoms need to be understood dynamically and can be treated by surgical resection by a thoracic surgeon.