Upstairs chest tightness shortness of breath dyspnea may be coronary atherosclerosis, chronic obstructive pulmonary disease, congestive heart failure and other diseases. 1. Coronary artery atherosclerosis: The development of coronary artery atherosclerosis may lead to narrowing of the blood vessels of the heart, resulting in insufficient blood supply to the heart muscle, and the symptoms of upstairs chest tightness, shortness of breath and difficulty in breathing will occur. 2. Chronic Obstructive Pulmonary Disease (COPD): Usually associated with airway and/or alveolar abnormalities caused by significant exposure to harmful particles or gases, patients present with dyspnea, shortness of breath and other manifestations. In later stages, the patient’s quality of life is severely affected and may have difficulty walking or walking up stairs to breathe. 3. Congestive heart failure: refers to the pathological state in which the heart’s working capacity (myocardial systolic or diastolic function) decreases, i.e., the cardiac output is absolutely or relatively insufficient to meet the needs of systemic tissue metabolism. The main manifestations are dyspnea, limitation of physical activity and fluid retention. Upstairs chest tightness shortness of breath dyspnea may also be seen in other causes, it is recommended to go to the hospital to clarify the cause of the disease under the guidance of the doctor for treatment.