Diabetes is not inherited from one generation to the next, but the probability of developing the disease in the grandchildren of people with diabetes may be relatively high. Diabetes is genetically predisposed to a certain extent, and parents with diabetes have an increased likelihood of developing the disease in their children’s offspring compared to the general population, but this cannot be called intergenerational inheritance. The concept of intergenerational transmission refers to the phenomenon whereby the offspring of an affected individual do not have the same disease, but their grandchildren or in the next generation do. Both type 1 and type 2 diabetes are inherited and most of them are polygenic. In addition to genetic factors, there are other factors that contribute to the increased risk of developing the disease, such as a long-term high-sugar diet, sedentary lifestyle, alcohol abuse, overweight or obesity, Cushing’s disease, and prolonged or high-dose glucocorticoid therapy. If you have diabetes in your family, you should control your diet, exercise appropriately, stop smoking and drinking, and monitor your blood glucose regularly. If necessary, seek timely medical treatment to reduce the risk of the disease.