Neurodermatitis is a neurological dermatosis characterized by mossy skin and intense itching. The root cause of this disease is the increased sensitivity of the nerve endings of the body, mood swings, nervousness, impatience, overwork, as well as local collar friction, scratching stimulation, etc. can promote the disease or make the disease aggravated. 1.Clinical manifestations Clinically, there are two types: limited type and generalized type. The localized type mostly occurs in the back of the neck or its two sides, elbow fossa, state fossa, forearm, thigh, calf and lumbosacral area. It is characterized by thickened skin, raised skin ridges, deepened skin furrows, resembling moss, and severe itching. Pancytopenia, also known as diffuse neurodermatitis, is a condition in which the above-mentioned damage is more obvious on the skin of the whole body, but is less common. Scratching often results in scratches, scabs or secondary infections, boils or folliculitis on the affected area and its surroundings. Prolonged disease can cause mental symptoms such as agitation, insomnia, fatigue, and memory loss. The disease has a chronic course, does not heal for many years, and is prone to recurrence. 2, treatment First of all, the correct diagnosis, such as eczema misdiagnosed as the disease is not curable. The traditional treatment is to stop itching, including oral antihistamines and even hormones, local topical hormonal ointment, local closure and other treatments. These treatments are more effective for occasional cases, but often only temporarily control the symptoms for the stubborn ones, which are easy to relapse and cause great physical and mental pain to the patients. Many patients and even some specialists believe that the disease cannot be cured. Through years of clinical practice and research, Dr. Lv Zhongfa, the chief physician of our department, has concluded that reducing the sensitivity of the nerve endings while supplementing with appropriate topical medication can achieve both primary and secondary treatment. This theory has been applied to cure hundreds of patients with persistent neurodermatitis without recurrence.