Dermatoglyphic spots can also be called subcutaneous spots, mainly referring to acquired nevus of Ota-like spots around the eyes, cheekbones, and neck with irregular shape and dark coloring, growing under the skin. It is often seen in young and middle-aged women, and may be related to genetics, endocrine, chemical precipitation such as cosmetics or hair dyes, as well as oral contraceptives and sequelae of liver and kidney disorders. Dermatoglyphic spots are mostly caused by the long-term use of irritating skin care products, chemical residues in the body, or long-term exposure to ultraviolet radiation, irregular work and rest, endocrine disorders and other factors that lead to further aggravation of the pigmentation in the epidermis of the skin, and the pigmentation gradually sinks in the dermis to form dermatoglyphic spots. Pigment spots can be removed by improving one’s living habits, avoiding staying up late, staying away from ionizing radiation, strengthening sun protection, preventing pigmentation, or by fractional laser, picosecond laser or surgical excision. Without damaging the normal skin, a specific wavelength of light beam is used to pass through the epidermis and reach the root of the spots, destroying the pigment cells and pigment particles, or gently decomposing and ablating the superficial skin pigments and smaller molecules of pigments to reduce the superficial skin discoloration. No matter what kind of treatment method is adopted, it needs to be adhered to. While undergoing treatment, avoid sun exposure, ensure sufficient sleep and nutritional support, and maintain a relaxed state of mind to prevent the continued formation of discoloration.