Fatty liver with enlarged spleen may be caused by congenital abnormal spleen development, cirrhosis causing enlarged spleen, complication of other diseases, etc. After clarifying the cause of the disease, it can be treated by adenosylmethionine and other medicines, surgery, radiotherapy and other ways. 1. Congenital abnormalities of spleen development: Fatty liver does not usually cause spleen enlargement, which can be considered to be caused by congenital problems, and surgical resection can be chosen in accordance with medical advice. 2. Spleen enlargement caused by cirrhosis: if the patient’s fatty liver is more serious, causing cirrhosis, which can lead to portal hypertension causing spleen enlargement, the patient should follow the doctor’s advice to use adenosylmethionine and other liver-protecting drugs, carry out transjugular intrahepatic portosystemic shunt to alleviate portal hypertension and other treatments, and pay attention to the prevention of wound infection after the operation, eat more protein-rich food, which will help recovery. 3. Complicated with other diseases: such as leukemia, etc., the spleen will be enlarged, which needs to be treated with symptomatic treatment and radiotherapy after the cause is clarified. It is recommended that fatty liver patients with enlarged spleen should go to the hospital in time for treatment.