Progesterone fertility treatment is suitable for women with luteal insufficiency, pre-eclampsia, previous history of spontaneous abortion, precious children, advanced pregnancy, and pregnancy with polycystic ovary syndrome. After a woman becomes pregnant, the corpus luteum begins to secrete estrogen and progesterone to maintain embryonic development. At 8 to 11 weeks is the transition period when the corpus luteum begins to shrink and the placenta begins to establish its function, which may cause fluctuations in progesterone levels. After that, the placenta will produce estrogen and progesterone to replace the function of the corpus luteum. If the corpus luteum cannot produce sufficient amount of progesterone, it will increase the risk of miscarriage for pregnant women. Therefore, our principle of fetal preservation is also to wait for the establishment of placental function until 10 weeks of gestation. However, a woman with low progesterone levels during pregnancy does not necessarily mean that a miscarriage will occur, only that the chances of miscarriage will increase. When you are using progesterone intramuscularly to preserve the pregnancy, it is important to note that it is best to fix a time of day when administering the medication. This time should preferably be in the morning. The difference between the injection time each day and the previous day should be limited to two hours. After 7 to 10 days of medication, depending on your schedule, you can come to the hospital to review your hormone levels and adjust the dose of medication according to your results. In order to ensure the evaluation of hormone levels, do not perform progesterone injection on the day of blood collection, when the blood collection is completed, the original dose of progesterone will be injected, and then we will adjust the next progesterone injection dose according to your results after the hormone results are released in the afternoon of the same day. When you use more than 20mg of progesterone, it is generally not recommended to stop the medication directly, but to gradually reduce the dose. In order to avoid large fluctuations of progesterone levels in the blood, which may cause vaginal bleeding and add unnecessary psychological burden to you. Therefore, it is recommended to always inject the progesterone at the original dose until the results are known, and only after the results are known will the dose be adjusted. Progesterone injection has been used by human beings for hundreds of years to preserve fetus. It is safe and reliable for use during pregnancy. Progesterone injection has the same structure as the progesterone produced by the body itself. Progesterone levels will increase after administration, but this does not mean that your own produced hormone levels have returned to normal. Rather, it is the result of supplementation after the medication is administered. We will gradually reduce the medication according to your hormone increase until you are able to produce a stable and sufficient amount of progesterone on your own. Usually, the placenta will be established around 11 weeks of pregnancy at the latest, and the body will produce a stable and sufficient amount of progesterone on its own, and the risk of miscarriage will be greatly reduced after 11 weeks. Progesterone injections, progesterone pills, progesterone capsules, progesterone softgels, and dydrogesterone tablets are the most commonly used progesterone preparations in clinical practice. All of these progestogen preparations are safe to use during pregnancy. In general, I personally recommend a combination of dydrogesterone and progesterone injection for fetal preservation during pregnancy. Progesterone injection is the most effective and the cheapest. It costs$0.67 a shot. The disadvantage is that you get a shot every day. Progesterone capsules, progesterone softgels, progesterone pills belong to the same category, all are micronized progesterone, their ingredients are no different from the progesterone injected intramuscularly, the price is higher, the cost of a day is often more than 10 dollars, the absorption effect is not as good as progesterone injection, the maximum daily dosage is not recommended to exceed 300mg, this dose is about equivalent to the dose of progesterone injection 30mg. A significant number of patients require supplemental progesterone injections in doses of 40-60mg, thus limiting the application of these drugs. Didrogestrel tablets, also costing$13 a day, are expensive but their composition is different from natural progesterone and is called reverse progesterone. It is made by a special process in which natural progesterone is irradiated with ultraviolet light. Current information shows that dydrogesterone is superior to natural progesterone in terms of fetal preservation. Therefore I chose to pair an inexpensive progesterone injection with a more expensive, but effective drug. To put it in layman’s terms, some protocols choose to combine progesterone injection + progesterone pills, but actually use only one drug. Progesterone injection + Didroxyprogesterone tablets are equivalent to using two medications for the same cost to preserve the pregnancy. Most women experience more or less abdominal discomfort during pregnancy, which is associated with emotional stress and pelvic congestion. It is not possible to determine whether the fetus is healthy or not. Emotional stress and low socioeconomic status can aggravate early pregnancy reactions. Therefore, it is advisable for pregnant women to relax their mind. The normal development of the fetus needs to be determined by hormone levels and ultrasound.