There are many medications available for the treatment of nongonococcal urethritis, which can be categorized into tetracyclines, macrolides, and quinolones in terms of the type of medication. Non-gonococcal urethritis, that is, refers to the exclusion of gonococcus, the causative agent of infection caused by the inflammatory reaction of the urethra. 1. Tetracyclines: commonly used drugs such as doxycycline and minocycline are broad-spectrum bacteriostatic agents that can inhibit mycoplasma, chlamydia, and atypical non-bacteriophages in addition to enterococci. 2. Macrolides: commonly used drugs are roxithromycin, azithromycin, clarithromycin, etc. They are mainly used for non-gonococcal urethritis caused by mycoplasma, chlamydia and ureaplasma urealyticum infection. 3. Quinolones: commonly used drugs are oxfloxacin, ciprofloxacin, norfloxacin, etc., mainly through the inhibition of bacterial DNA synthesis, so as to achieve the purpose of sterilization, can be treated for non-gonococcal urethritis caused by E. coli, Klebsiella, dysentery bacillus, Aspergillus spp. Salmonella spp., Mycoplasma chlamydia, Staphylococcus aureus, and other pathogenic bacteria infections. Antibiotic drugs may have gastrointestinal reactions, as well as drug liver damage, and may cause allergic reactions, etc., you need to go to the hospital for examination first, under the guidance of the doctor to use drugs, to avoid their own abuse of antibiotics.