Proper use of doxycycline does not usually result in hematuria. Doxycycline is a semi-synthetic tetracycline antibiotic derived from oxytetracycline, which is a broad-spectrum antibacterial agent and can effectively sterilize at high concentrations. It is mainly used for the treatment of rickettsial disease, mycoplasma genus infection, chlamydia genus infection, cholera, Lyme disease, regression fever and other diseases. It should be noted that long-term application or abuse of doxycycline can lead to a variety of complications, including hepatic and renal impairment, thrombocytopenia, coagulation dysfunction, and in severe cases can cause hematuria, but in clinical practice is relatively rare. Doxycycline is a prescription drug and should only be used when prescribed by a physician and should not be used without authorization. When using doxycycline, you should follow the doctor’s instructions, including the correct time, usage, dosage, etc. Do not change the dosage or usage on your own. In conclusion, hematuria does not usually occur when doxycycline is used correctly as prescribed by the doctor. If hematuria occurs while taking the medication, it is recommended to go to the urology department of the hospital in time to clarify the cause and treat it actively.