A small red dot on the hand like a needle’s eye could be AIDS or a skin disease, depending on the circumstances. The incubation period of AIDS is usually asymptomatic. After the onset of the disease, there may be small red dots on the hands like needle eyes, but they may be accompanied by fever, sore throat, swollen lymph nodes, headache, diarrhea, muscle aches and weakness, etc. These small red dots can usually recover on their own with the development of the disease. In addition, in the late stage of the disease, the patient’s immunity is low and he is susceptible to various bacterial, fungal, viral and parasitic infections, which may also lead to pinhole-like red dots on the hands, accompanied by skin ulcers, blisters, red papules, patches and other symptoms. However, if the patient only has small red dots on the hands and has no other manifestations and has not been in contact with AIDS patients, it is mostly due to skin disease and can be treated in dermatology. If the patient has high-risk behavior of AIDS and has small red dots like needle eyes on his hands, he can go to dermatology or infection department for laboratory test. If the test is positive for AIDS antibody, it means the red dots may be caused by AIDS.