Taking antipyretic medication does not immediately cause sweating and fever reduction; it takes some time for the fever to subside. The fever is due to the thermogenic source adjusting the temperature regulation point of the body temperature center, resulting in increased heat production and decreased heat dissipation of the body, through the liver, muscle and other organs increased heat production, skin contraction, resulting in reduced blood flow, resulting in increased body temperature and cold extremities, so there will be no sweating, and as the temperature regulation point decreases, reaching a certain temperature, the body will adjust to increase heat dissipation, the patient appears to sweat profusely. And the reasons for not sweating when taking antipyretic drugs are: 1. The degree of inflammation is heavy. This leads to excessive thermogenic sources, the body temperature regulating point is maintained at a high level, and the effect of conventional antipyretic drugs is weak. 2. The patient is dehydrated. Due to the reduction of body water, which leads to the reduction of circulating blood flow and skin blood flow, resulting in the normal secretion of sweat glands. 3. Central fever. It is due to the disease of the temperature regulation point itself, not caused by the thermogenic source, thus antipyretic drugs are ineffective, and the body does not have a cooling reflex such as sweating.