Generally speaking, the conversion of major triple-positive to minor triple-positive indicates that the hepatitis B virus replication in the HBV-infected person is reduced and less infectious to the surrounding public. At the same time, liver function should be normal and HBVDNA negative. This type of “small triplet” is better than “large triplet”. If the “major triplet” turns into “minor triplet”, but the liver function is abnormal and HBVDNA is positive, it indicates the emergence of a mutant strain of hepatitis B virus, which is the absolute dominant strain (the emergence of mutant strains is due to immune selective pressure, in fact, there are also mutant strains in major triplet). (The presence of mutant strains is due to immune selective pressure, but there are also mutant strains in the major triplet, but they are not the dominant strain). The mutant strain can effectively evade the body’s attack, leading to years of latent development of liver inflammation and eventually cirrhosis and liver cancer. Most of the patients with cirrhosis and liver cancer are small triple-positive. There are also cases where “small triplets” develop into severe hepatitis. These patients should be treated and reviewed regularly. However, due to many factors such as work tension or layoff or economy, some “small triple positive” patients do not have AFP, B-ultrasound and liver function tests in a timely manner, and as a result, they have advanced primary liver cancer, which is very sad. ”Small triplets” are not always better than “big triplets”, regardless of “small triplets” or “big triplets”, all of them should be tested regularly. Regular outpatient tests for AFP, ultrasound, HBV-DNA and liver function are necessary to detect cirrhosis and liver cancer as early as possible and provide timely treatment.