The term “major triple-positive” generally refers to HBsAg positive, HBeAg positive and core antibody positive in two pairs of half-positive, while “minor triple-positive” is usually one less HBeAg positive. We often hear patients “compare” each other in outpatient clinics, and patients with “small triplets” are often happy, while patients with “large triplets” are envious, but Is “major triple-positive” necessarily more serious than “minor triple-positive”? This is not the case. First of all, there are different situations for “major triplets”: if a “major triplet” patient is positive for hepatitis B virus DNA and has active viral replication, but if liver function remains normal, this means that the patient is in the immune tolerance period, during which the liver tissue is not significantly inflamed and The body coexists peacefully with the hepatitis B virus, and the condition is stable and does not require treatment. This is certainly not a bad thing. However, if a patient with “major triple yang” has liver function abnormalities, such as increased transaminases, which cannot be recovered within six months, and are not caused by other factors, it means that the body has entered the immune clearance period, and the liver has been significantly verified and the liver cells are damaged, which requires drug treatment. In addition, the “small three yang” is not necessarily restless: “small three yang” patients if the hepatitis B virus DNA negative, transaminases normal, and the surface antigen level is low or even disappeared, indicating that at this time in the inactive or low replication period, that is, the immune control period. This is indeed the best state for the treatment of slow hepatitis B. However, if the patient is still positive for hepatitis B virus, it means that the disease is active again, which is often combined with abnormal liver function, and becomes a small triple-positive hepatitis. Although the viral replication is not as high as in patients with major triple-positive hepatitis, and the transaminases are often only mildly abnormal, most patients are older and have previous liver inflammation, and liver damage can easily develop into cirrhosis and liver fibrosis. From this perspective, “small triplets” are more serious than “large triplets”. In conclusion, the condition of slow hepatitis B is complex, and there are many different types of hepatitis B. We cannot arbitrarily judge the severity of the disease based only on whether it is “major triplet” or “minor triplet”, but must combine it with other tests such as surface antigen, liver function and hepatitis B virus DNA. We need to combine surface antigen, liver function, hepatitis B virus DNA and other tests to make a comprehensive judgment.