Ultrasensitive C-reactive protein is a C-reactive protein in plasma, also known as high-sensitivity C-reactive protein. I. Structure C-reactive protein is a non-specific marker of the acute phase of systemic inflammatory response synthesized by the liver, and is one of the most powerful predictors of risk of cardiovascular events. The hs-CRP ultrasensitive C-reactive protein is an ultrasensitive detection technique used in clinical laboratories to accurately detect low concentrations of C-reactive protein, which improves the sensitivity and accuracy of the test and is a sensitive indicator to distinguish low-level inflammatory states. serum hs-CRP levels are closely related to the occurrence, severity and prognosis of atherosclerosis and acute cerebral infarction (ACI). II. Pathology In elderly patients with acute cerebral infarction, those with elevated CRP have poor prognosis; hs-CRP level correlates with infarct size and degree of neurological deficit, and is one of the indicators of the degree of lesions in patients with cerebral infarction; moreover, CRP is also involved in the pathological process of thrombosis and atherosclerosis, and is one of the risk factors for stroke. The inflammatory response of atherosclerotic plaques is an important cause of plaque rupture and instability. During the formation of atherosclerotic plaques, CRP, complement complexes and foam cells are deposited in the arterial wall, and CRP can bind to lipoproteins, activate the complement system, produce a large number of inflammatory mediators, release oxygen free radicals, cause intimal damage, vasospasm and unstable plaque detachment, aggravate the atheroma The development of luminal stenosis and ACI due to atherosclerosis is aggravated. There is increasing evidence that low levels of CRP are closely associated with other risk factors for cardiovascular disease, such as hypertension and hyperlipidemia; at the same time, elevated CRP increases the incidence of heart disease and stroke in hypertensive patients; therefore, CRP is a pro-inflammatory factor associated with the occurrence, evolution and development of atherosclerosis. Epidemiological surveys have also shown that people with elevated hs-CRP levels are twice as likely to have an acute stroke and three times as likely to have a myocardial infarction as normal healthy people. 2003 European guidelines for the prevention and treatment of hypertension (ESH/ESC) formally recommended that hs-CRP levels be tested in hypertensive patients. The clinical guidance of ultrasensitive C-reactive protein is mainly for cardiovascular disease, neonatal bacterial infection, and renal transplantation. III. Conditions in which CRP is elevated Acute or chronic inflammatory disease; tissue necrosis or tissue injury; tissue ischemia or infarction; infection, inflammation; metabolic syndrome; malignancy, especially breast, lung, and gastrointestinal tumors; acute pancreatitis; post-surgery; burns; leukemia; tobacco smoke; hormone replacement therapy; obesity. IV. Limitations Gender and race can affect CRP levels. African-Americans have higher CRP levels than Caucasians, and women have higher CRP levels than men. samples for CRP collection are whole blood serum, plasma. CRP is an acute chronophasic serum protein that is a substitute for the pro-inflammatory interleukin IL-6. CRP can also be produced by blood vessel wall cells, such as endothelial cells, smooth muscle cells, and can be synthesized by adipose tissue.