Femoral head necrosis is mainly due to the interruption of blood to the femoral head as well as damage, causing destruction, deformation and collapse of the femoral head. For some patients with mild symptoms of early stage osteonecrosis of the femoral head, medication can help relieve the symptoms, reduce the patient’s pain and help maintain the normal physiological function of the femoral head. There are three major classes of drugs commonly used clinically to treat osteonecrosis of the femoral head. The first major class of drugs is non-steroidal anti-inflammatory drugs. By taking NSAIDs, patients can help reduce the pain and swelling caused by osteonecrosis of the femoral head, helping to alleviate their pain and improve their quality of life. The second major class of drugs is anticoagulants. Patients can take low molecular heparin and corresponding Chinese herbal medicines to activate blood circulation and remove blood stasis, which can help improve hypercoagulability, promote blood circulation in the femoral head and nearby tissues, and prevent the occurrence of vascular embolism. The third major class of drugs commonly used in clinical practice are drugs that regulate bone metabolism. These drugs can help prevent the collapse of the femoral head and avoid aggravation of the condition. In addition to using the above three major classes of drugs, vasodilators, cholesterol-lowering drugs, and anti-swelling drugs can also be used to help control the patient’s condition. The reasonable use of non-steroidal anti-inflammatory drugs, anticoagulants, and drugs to regulate bone metabolism is very effective in treating early-stage femoral head necrosis, which can help relieve symptoms, inhibit the development of the disease, and improve the patient’s quality of survival. However, once the disease progresses and the symptoms become obvious, the patient should actively receive surgical treatment.