Patients who get headaches when they smell smoke are mainly considered to have vasoneurotic headaches, migraines, allergies and other causes. Patients who smell cigarette smoke are equivalent to passive smoking. Usually, this symptom can be relieved within a few hours when patients get out of the passive smoking environment and go out to breathe fresh air in time: 1. Vascular neurological headache: such patients may suffer from an excess of harmful substances such as tobacco tar, nicotine and carbon monoxide contained in cigarettes, which may cause insufficient oxygen supply to the brain and then cause transient cerebral ischemic attacks, thus manifesting as headache; 2. Migraine: Patients with long-term migraine can also experience headache after smelling cigarette smoke, because nicotine in cigarettes can stimulate the brain nerves through olfaction, promote the release of substance P, calcitonin gene-related peptide and other neuropeptides, which can act on patients’ cerebral blood vessels to cause vasodilatation and headache; 3, allergy: Some patients who are allergic to certain components of cigarettes can also experience headache when smelling cigarette smoke, which can be accompanied by Skin reddening, arrhythmia, chest tightness and shortness of breath; 4, cerebrovascular disease: for people with cerebrovascular disease, smoking will cause the oxygen content of their own blood to drop, resulting in insufficient oxygen supply to the brain, which can trigger transient cerebral ischemic attacks, headaches, dizziness and other symptoms. Therefore, the above-mentioned patients should stay away from the smoking crowd, stay away from the smoking environment and exercise appropriately to enhance their own physical fitness, while patients with chronic severe headaches should seek medical attention and take oral pain medication, such as ibuprofen extended-release capsules, if necessary, under the guidance of a doctor.