If a patient has chest tightness accompanied by nausea and vomiting, there are several possibilities: first, cardiogenic diseases, such as coronary atherosclerotic heart disease, unstable angina, myocarditis, pericarditis, heart valve disease, hypertrophic obstructive cardiomyopathy, and congenital heart disease, may have the above symptoms. Secondly, diseases of the respiratory system, such as chronic bronchitis, bronchiectasis, chronic obstructive pulmonary emphysema, pulmonary heart disease, and pulmonary hypertension, may also cause chest tightness and distension, nausea, and vomiting due to insufficient arterial oxygen saturation. Then, digestive system diseases, such as acute gastroenteritis, bile reflux gastritis, gastroduodenal ulcer, esophagitis, can also occur with chest tightness accompanied by nausea and desire to vomit. Finally, patients with ionic disorders, such as hypokalemia and hyponatremia, may also have such clinical symptoms and manifestations.