Hyperthyroid crisis is the most serious complication of hyperthyroidism, with a mortality rate of about 20% to 50%. The main manifestation is hyperthermia, with body temperature above 39℃. There are also cases with atypical clinical symptoms, such as profuse sweating, vomiting, diarrhea, tachycardia, restlessness, delirium and coma. Once a critical condition occurs, comprehensive measures should be taken immediately for resuscitation. Generally, the following measures should be taken: 1. Propylthioxypyrimethamine is preferred to inhibit thyroid hormone synthesis, and methylthioxypyrimethamine, tabazol, and hyperthyroidism are also available. The dosage of propylthioxypyrimethamine is 200-300 mg orally or intranasally every 6 hours, and the effect starts 1 hour after taking the drug. In case of delirium, the drug can be crushed and injected through the gastric tube. 2. Inhibition of thyroid hormone release Inorganic iodine solution can be used to block the secretion of thyroid hormone by administering a large amount of iodine solution intravenously or orally within 1 hour after antithyroid drug treatment. The method is to take about 30 drops of compounded iodine solution orally daily and gradually stop using it within 2 weeks. If the symptoms do not improve and worsen after 1 to 2 days of comprehensive treatment, peritoneal dialysis or hemodialysis can be used to bring down the plasma T4 concentration. 3. Rapid blockade of catecholamine release. In the absence of heart failure, asthma and atrioventricular block, generally 10 to 40 mg of take-home pay is given orally every 4 to 6 hours; or 0.5 to 1 mg intravenously, and then repeat treatment or increase the amount of slow sedation if necessary. There are also useful tips 1 ~ 5 mg sedative, or 40 ~ 80 mg every 6 hours orally, the symptoms can be improved after a few hours of medication. Lixin 1~2 mg intramuscular injection every 4~6 hours can make the tissue stored catecholamines depletion, and the dosage can block its effect when larger, or guanethidine 1~2 mg/kg body weight orally daily. 4. adrenocorticotropic hormone. It can inhibit the release of thyroid hormone, reduce the conversion of T4 to T3 and correct the relative adrenocortical insufficiency in critical conditions. Commonly used drugs are hydrocortisone 200-500 mg/day or dexamethasone 15-30 mg/day, IV. For patients with high fever, profuse sweating and coma, dexamethasone 5-10 mg can be pushed quietly, and then hydrocortisone or dexamethasone is used to maintain the static point, and the dose is gradually reduced or even discontinued after the symptoms are reduced. Symptomatic management: including the use of drugs or physical methods to lower the body temperature, avoid the use of salicylates to lower the temperature, oxygen, supplementation of water, electrolytes, vitamins, etc., sedation can be used when irritable, artificial hibernation if necessary. Give high-calorie, high-protein and high-sugar diet, strengthen supportive therapy, and maintain water and electrolyte balance. In case of infection, give appropriate antibiotics. Actively remove the causative factors.