Thyroid cancer: the solid cancer with the fastest increasing incidence 1. incidence rate increases by 6.2% per year (US data); 2. importance: 5-15% of thyroid nodules are cancer; 3. special medical history suggesting malignant possibility; 4. childhood history of head and neck radiation exposure; 5. family history of thyroid cancer; 6. first-degree relatives with certain thyroid cancer syndromes (Cowden syndrome, familial intestinal polyposis, Carney syndrome Carney syndrome, MEN2, Werner syndrome, etc.); 7. History of radioactive dust exposure in childhood or adolescence; 8. Rapidly increasing nodules; 9. Hoarseness or vocal cord paralysis; 11. Enlarged cervical lymph nodes ipsilateral to the nodule; 12. Relative fixation of the nodule to surrounding tissues; 13. Laboratory and imaging tests; 14. TSH should be checked for thyroid nodules >1 cm; 15. If TSH is elevated, or even just close to the upper limit of normal, the nodule needs to be evaluated, and the rate of nodule malignancy is higher at this time; 16. Ultrasonography should be performed for known or suspected nodules (hypoechoic, rich blood supply in the nodule, irregular margins, microcalcifications in the nodule, halo absence or nodule height exceeding width, etc., and infiltrative lesions in the cervical lymph nodes); 17. 18. Routine serum calcitonin testing is neither supported nor opposed; 19. FNA (or ultrasound-guided FNA) is the most cost-effective and accurate preoperative evaluation method, generally used for nodes >1 cm, and suspicious nodes >5 mm can also be used.