What causes cirrhosis of the liver?

  Liver cirrhosis is a common chronic liver disease that can be caused by a variety of reasons. Diffuse degeneration and necrosis of hepatocytes, followed by fibrous tissue proliferation and nodular regeneration of hepatocytes, are repeatedly intertwined, resulting in the gradual modification of the structure of liver lobules and blood circulation pathways, causing liver deformation and hardening to form cirrhosis. In the early stage of the disease, there may be no obvious symptoms, but in the later stage, a series of different degrees of portal hypertension and liver dysfunction may appear.  Cirrhosis is a chronic liver disease caused by long-term damage to the liver from one or more etiologies, with progressive, diffuse, fibrous lesions in the liver. The main clinical manifestation is impaired liver function with portal hypertension. Complications such as upper gastrointestinal bleeding and hepatic encephalopathy are often seen in the late stage.  There are many causes of liver cirrhosis, and the following factors can cause cirrhosis.  1, viral hepatitis In China, viral hepatitis (especially type B and C) is the main cause of cirrhosis, most of which develop into portal cirrhosis. Hepatocytes of patients with cirrhosis often show HBsAg positivity, with a positivity rate of 76.7%.  2, chronic alcoholism In Europe and the United States due to alcoholic liver disease caused by cirrhosis can account for 60% to 70% of the total.  3, nutritional deficiencies Animal experiments have shown that animals fed foods lacking in choline or methionine can develop into cirrhosis through fatty liver.  4, poisoning certain chemical toxins such as arsenic, carbon tetrachloride, yellow phosphorus and other long-term effects on the liver can cause cirrhosis.