Introduction: Many modern women are taking birth control pills to prevent pregnancy, but do you know the contraindications of taking birth control pills? There are several drugs can not be taken with the contraceptive pill. 1, rifampin: it is commonly used anti-tuberculosis drugs, can make oral contraceptives the main components of the metabolism of norethindrone and ethinyl estradiol to speed up, reduce the concentration of drugs in the blood, and may make the endometrium partly shed and spot bleeding or dripping, while reducing the effectiveness of contraceptive drugs and lead to contraceptive failure. 2, antimicrobial: someone had 38 taking contraceptives at the same time with ampicillin, neomycin, tetracycline, cotrimoxazole, chloramphenicol and lead to contraceptive failure of women to observe, found that the reason for its failure is that antimicrobial inhibits the intestinal bacteria, so that the number of glucuronidase produced greatly reduced, thus affecting the absorption of contraceptives in the intestine, so that the concentration of contraceptives in the blood decreased and can not achieve contraception effect. 3, anti-epileptic drugs: these drugs are enzyme inducers, such as phenobarbital, phenytoin, carbamazepine, paracetamol, etc.. When women with epilepsy take these drugs, can promote the increase of drug metabolism enzymes in liver cells, accelerating the destruction of oral contraceptives, but also increase the rate of progestin and globulin binding, so that the free progestin concentration is greatly reduced, resulting in the failure of contraception. 4, ashwagandha: this is an antifungal drug, it can change the activity of liver granulomatous enzymes when used with contraceptives, so that the concentration of steroid hormone decreases and menstrual blood, leading to contraceptive failure. Foreign has reported more than 20 women taking birth control pills, after taking ashwagandha, there are 15 menstrual blood reduction, 5 amenorrhea, 2 pregnancy. 5, enzyme enhancers: such as sleepy sleeper drugs, such as sleepy sleeper drugs, rheumatoid arthritis treatment drugs such as Po Tai Song. These drugs have enzyme-promoting effect, can promote the metabolic activity of the liver granule enzyme-catalyzed drugs, accelerate the metabolism of oral contraceptives, reducing the effectiveness of contraception. If you have to use sleeping pills, you can use Valium instead, do not take other sedative sleeping pills.