Granulomatous mastitis is an immune disease, the incidence of which has been increasing in recent years, but many patients do not know enough about it and take many detours in its treatment. Moreover, the disease is often misdiagnosed by clinical doctors, leading to recurrent attacks of granulomatous mastitis, which eventually develop into redness and ulceration and have to be treated surgically. In fact, patients with this disease often have sudden onset of breast lumps that develop rapidly after triggers such as anger. Breast lumps are hard and painful and are not associated with bacterial infection, so they are different from breast infection diseases because breast infections, although red and swollen, rarely go through a period of sudden non-red and hard lumps. The disease is also essentially different from plasmacytoid mastitis, which mostly has nipple invagination, a long history of disease, and no history of severe pain or sudden onset of hard lumps; the disease is also different from inflammatory breast cancer, which often occurs during lactation, with persistent high fever and hard lumps that do not have a localized softer presentation. If granulomatous mastitis can be diagnosed at the early stage of development, or if the clinical doctor takes the disease into account, surgery can be completely avoided. Even in severe granulomatous mastitis, as long as the disease can be taken into account, treatment will be targeted to achieve the purpose of controlling the disease, timely treatment and taking into account the cosmetic appearance of the breast. Because granulomatous mastitis is often difficult to distinguish from breast cancer clinically, histopathological examination by gross needle aspiration biopsy or surgical biopsy is required. The main pathological change is granulomatous lobulitis, which consists of granulomas with epithelioid histiocytes, multinucleated giant cells, accompanied by lymphocytes, plasma cells, and occasionally eosinophilic infiltration, abscesses containing polymorphonuclear leukocytes and fibrosis formation that can mask lobulocentric The distribution is characteristic. In women with a recent history of childbearing, localized lactational changes of the lobules can be seen, and the ducts at the lesion may appear dilated, showing periductal or intraductal inflammation, but usually not significant, with negative bacterial, antacid, and fungal cultures and stains.