(Disclaimer: This article is for scientific purposes only. In order to protect Ms. Xie’s privacy, the relevant information in the following content has been processed) Abstract: The main character of this case is a 30-year-old Ms. Xie, who has a 3-year history of diabetes mellitus. Due to the recent poor glycemic control, coupled with the cloudy and rainy weather, Ms. Xie developed vulvar itching and abnormal leukorrhea, which appeared as tofu dregs. She was diagnosed with candidiasis after vaginal discharge results indicated a cleanliness level of IV and positive for Candida. We gave Ms. Xie medication to help fight Candida, and also instructed her to regulate her blood sugar. After treatment, the vaginal secretion test returned to normal, and the treatment effect was good. Basic information] Female, 30 years old [Type of disease] Candidiasis [Hospital] Jiangbin Hospital, Guangxi Zhuang Autonomous Region [Time of consultation] January 2022 [Treatment plan] Medication (Fluconazole tablets + clotrimazole suppositories + Maternity Health Wash) [Treatment cycle] Outpatient treatment for 10 days [Effect of treatment] Review of the vaginal secretion examination returned to normal, the effect of the treatment is good I. Initial consultation Ms. Xie’s history of diabetes is 3 years. Ms. Xie has a history of diabetes mellitus for 3 years and has been taking glipizide tablets and metformin hydrochloride extended-release tablets to control her blood glucose. At the time of consultation, Ms. Xie reported that she had been experiencing rainy weather recently, and felt that her clothes and pants were not drying in the sun. She started to have mild itching of the vulva after her menstrual period one week ago, and found that her leukorrhea increased and became tofu-slag-like, and then the itching gradually worsened, and she had enlarged her vulva and labia. Gynecological examination: vulva and labia majora and minora were red and enlarged, with scratches; vaginal discharge was abundant and white and tofu-dreg-like; uterus and adnexa were normal in size, with no pressure pain. Vaginal secretion examination: cleanliness Ⅳ degree, positive for Candida. Diagnosed with candidiasis and treated with medication on an outpatient basis. （As the result of vaginal secretion examination indicated that Candida was positive, the diagnosis of “candidiasis” was clear, and outpatient medication was given. Fluconazole tablets were used as oral systemic medication, together with clotrimazole suppositories for topical treatment of candidiasis, and at the same time, Maternity Wash was given to be diluted for daily sitz baths, which had the effect of relieving itchiness and sterilizing the bacteria. The doctor explained to Ms. Xie that the occurrence of candidiasis is very much related to diabetes mellitus, and suggested that she should pay attention to monitoring her blood glucose over the past few days, and adjust the dosage of hypoglycemic drugs to control her blood glucose if necessary. At the same time, Ms. Xie should change and wash her underwear, wear more sunshine, wear loose cotton underwear as much as possible, avoid sexual intercourse during the treatment period, develop good dietary habits, eat less hot and stimulating food, and avoid scratching the vulva. Treatment effect After 4 days of treatment, Ms. Xie felt that the symptoms of vulvar itching were significantly reduced, and the leukorrhea decreased, so she followed the doctor’s instructions to use the medication for a total of 7 days. On the 3rd day after stopping the medication, Ms. Xie went to the outpatient clinic for follow-up, and the gynecological examination showed that the vulva and labia majora and minora had returned to normal, with no redness or swelling, and not much vaginal secretion. Vaginal secretion examination: cleanliness II degree, Candida negative, the indicators returned to normal, indicating that the treatment is effective. Ms. Xie’s blood glucose monitoring at home revealed that her blood glucose was high recently, and after adjusting her medication and paying attention to her diet, her blood glucose returned to the normal range. Precautions We are glad that Ms. Xie’s symptoms have improved after treatment, and the following points should be noted in the follow-up: 1. High blood sugar is a common cause of candidiasis, so we suggest Ms. Xie to actively lower her blood sugar, control her blood sugar, and adjust the glucose-lowering medication if necessary; 2. Candidiasis is easy to recur, so we suggest that Ms. Xie should repeat her first review of vaginal secretion to check for Candida negative, then repeat her review again one week later, and repeat her review after she has been negative twice, indicating that the treatment has been completely cured; 3. Avoid sexual intercourse during the treatment period, general male infection is rare, if the husband appears to be infected, it is recommended to actively treat, to be cured on both sides before sexual intercourse, otherwise it is easy to infect each other for a long time and difficult to cure; 4, Candidiasis is easy to treat, but it is also easy to recur, Ms. Xie is prone to adverse psychological effects, if necessary, it is recommended that Ms. Xie communicate with the doctor to reduce the triggers of recurrence from life. If necessary, Ms. Xie is advised to communicate more with her doctor and reduce the triggers of recurrence from her life to lower the chance of recurrence. V. Personal insights Women’s vagina will normally host some Candida, due to the number is not large, usually does not cause disease, but when there is an increase in blood glucose, resulting in changes in the vaginal environment, will cause Candida breeding, and vulvar, vaginal itching, leukorrhea increased such as tofu dregs, vulvar swelling and so on. As in this case, there is no need to worry too much at this time, timely medical treatment, usually through systemic or local antifungal treatment, can soon be cured. However, the disease is prone to recurrent attacks, so Ms. Xie should pay attention to removing the triggers that caused the attack after cure to avoid recurrence of candidiasis.