Helicobacter pylori (HP) infection is the most common cause of chronic gastritis and gastroduodenal ulcer, and is also one of the most important causes of gastric cancer. Once HP infection is detected, in principle, it should be eradicated by medication; HP is more resistant to antibacterial drugs, and the success rate of single drug treatment does not exceed 50%. The so-called “triple therapy” or “triple therapy” refers to the use of one proton pump inhibitor or bismuth citrate plus two antibacterial drugs (schedule) for 10-14 days, while the “quadruple therapy” uses one proton pump inhibitor + bismuth citrate + two antibacterial drugs. The criterion for successful eradication of HP infection is to stop taking the medication for more than one month and have a negative test (medication that does not affect HP does not have to be stopped). It is wrong to call it triple therapy or quadruple therapy after taking three or four drugs, and it is also wrong to review the cure as soon as the drugs are stopped. For adults who have failed treatment, I more often use the quadruple 10 days + 20 days program, the effect is good, as follows: the first stage of the quadruple drug 10 days, that is, omeprazole (20mg, bid), amoxicillin (1g, bid), furazolidone (0.2g, bid), bismuth raffinate (240mg, bid); the second stage of bismuth raffinate alone (240mg , bid) for 20 days. The reason for choosing this regimen is that resistance to these drugs rarely occurs. It should be reminded that (1) furazolidone can cause extremely yellow urine, and bismuth borate can cause black tongue and stool. This is not a side effect, so there is no need to panic. ② There are various names of bismuth raffinate such as bismuth gum, Lizudra, etc. The number of doses is usually 4 times/day as described in the instructions. However, for the convenience of taking the medicine, please divide the 4 times dose into two doses in the morning and evening; ③ patients with sericea should not use this regimen because of the risk of hemolysis caused by furazolidone. Glucose-6-phosphate dehydrogenase deficiency (G-6-PD deficiency). Exhibit. Drugs commonly used in the treatment of H. pylori Proton pump inhibitors (choose 1) Antibacterial drugs (choose 2) Omeprazole (20 mg, bid) Metronidazole (0.4, bid) Pantoprazole (40 mg, bid) Amoxicillin (1 g, bid) Lansoprazole (10 mg, bid) Clarithromycin (0.5 g, bid) Rebeprazole (10 mg, bid) Furazolidone ( 0.2g, bid) or bismuth citrate (240mg, bid) levofloxacin (0.5g, qd) Note: metronidazole, clarithromycin resistance is becoming increasingly serious, the initial treatment failed and the patient is generally not considered to choose; bid twice a day; qd once a day; amoxicillin (1g, bid) means each time to take 1g, twice a day, the rest of the analogy.