Infected bone discontinuity is usually caused by a wound infection that leads to a deep infection such as osteomyelitis, resulting in a bone defect bone discontinuity. This kind of bone discontinuity re-operation can easily lead to bacterial infection rekindling and treatment failure. The principle is to treat in stages, after the first stage of treatment of osteomyelitis and complete cure. Do not expect to cure osteomyelitis and osteoclastic bone discontinuity in one surgery. The patient had an open comminuted fracture of the subtrochanteric femur caused by a car accident 2 years ago, and the DHS staple plate fixation was performed after debridement at that time. About 6 months after the operation, the wound broke down and flowed pus, and the infection was considered. The wound healed quickly, and after about 8 months of observation, the wound was free of redness and swelling, and the hematocrit CRP was normal. The wound became infected and ruptured 10 days after surgery and has not healed since. There was pus in the surgical wound and the temperature was 37.5. E. coli was cultured and was drug resistant. X-rays showed that the fracture of the left femur was not healed and formed a bone defect with sclerosis of the broken end and dead bone after the surgery with internal fixation of the reconstructive nail. Analysis of the main problems: 1. Both internal fixation procedures were infected. 2, dead bone in the wound 3, the fracture does not heal, forming a bone defect and sclerosis of the broken end. Diagnosis: postoperative left femoral subtrochanteric fracture, non-healing fracture, chronic osteomyelitis Treatment measures: 1. Remove the internal fixation and dead bone to completely cure the osteomyelitis. 2.Adopt an external fixation frame for temporary fixation to maintain the position and length of the broken end. 3, implantation of antibiotic chain, pus or secretions from the lesion for culture, the use of sensitive antibiotics The author’s experience is homemade vancomycin chain beads. Vancomycin can kill many drug-resistant bacteria. In 20 grams of bone cement powder you can add 2.0 grams of vancomycin, mix thoroughly and then add liquid monomer, make soybean-sized particles after entering the dough phase, prepare into chain beads by threading a double-stranded fine steel wire, and wait for curing to implant into the bone marrow cavity of the lesion area. 4, 2 stage then do bone graft repair surgery for bone discontinuity, to do the necessary examination and stimulate infection test to confirm that the surgery will not cause the recurrence of infection before surgery.