Hepatomegaly can be caused by many diseases and is an important clinical sign. The position of the liver is related to gender, age, and body type, and may change to some extent with breathing, visceral activity, and body position. Infectious causes of hepatomegaly 1, viral hepatitis Patients who have been carrying the hepatitis B virus for a long time show fatigue, loss of appetite, nausea, aversion to oil, pain in the liver area, etc. The liver is large and accompanied by pressure pain on palpation, and patients with local hepatitis will have mild splenomegaly with abnormal liver function. Acute obstructive purulent cholangitis is caused by bacterial infection, which can lead to hepatomegaly due to liver congestion and bile accumulation, and the liver is mostly slightly or moderately enlarged, often accompanied by pressure pain, and sometimes accompanied by enlarged spleen symptoms.