Preterm newborns with low albumin can be observed first, and if accompanied by edema, severe jaundice, etc., human albumin can be given to correct the problem. Premature newborns with immature liver development may have low albumin, which can be observed regularly. If low albumin is accompanied by edema and severe jaundice in preterm newborns, prompt medical attention is needed to reduce edema and treat jaundice under the guidance of the doctor, and then human albumin can be given to correct the problem according to the condition, which will help the recovery and treatment of the disease. Low albumin may affect the resistance and development of the newborn, so preterm newborns with low albumin should consult a doctor in time, and under the guidance of the doctor to take appropriate measures according to the severity of the disease. After the treatment, we should follow the doctor’s instructions to review the baby regularly and observe the condition dynamically.