Malocclusion has polygenic inheritance characteristics and has a tendency to run in families. Many children inherit the characteristics of their parents in terms of dental alignment and craniofacial morphology. There are three ways in which hereditary malocclusion manifests itself: 1) the malformation is directly reproduced between parents and children; 2) the malformation appears intermittently between generations, also known as transgenerational inheritance; 3) the variation manifests itself i.e. the malformation manifests differently between generations, between offspring and parents, but in fact the genes of the offspring are linked to those of the parents. This genetic characteristic is affected by various aspects such as growth environment, bad habits and nutritional disorders will have variation. Many times it manifests as a non-directive recurrence with the parents. Some scientists have conducted longitudinal studies of growth and development and concluded that bony holdings are highly heritable, such as abnormal facial proportions and jaw relationships. Common symptoms of hereditary malocclusion include: abnormal upper and lower cranial shape or size, protrusion of both jaws or dental arches, anterior protrusion of the upper or lower jaw, or perhaps recession of the upper or lower jaw. Craniofacial narrowing, high arches of the palatal cover, deep overlays, deep overbite, crowded teeth, abnormal tooth morphology and number, and cleft lip and palate. The orthodontic treatment of hereditary malocclusion is more difficult and needs to be carried out early, with attention to long-term follow-up monitoring, and in some cases with the help of orthognathic surgical treatment in adulthood to achieve better results. For children in the teething stage, we can predict the future development of malocclusion from medical history, family history and X-rays.