In the case of premature coronary artery disease, the first thing that needs to be done is to treat the coronary artery disease, which can be treated with medications such as aspirin, metoprolol, nifedipine, atorvastatin, isosorbide nitrate, and so on. Secondly, antiarrhythmic drugs can be used to treat premature beats, such as propafenone, amiodarone and so on. Usually premature beats in coronary artery disease, the first need to actively treat the primary disease, the use of aspirin, metoprolol, nifedipine, atorvastatin, isosorbide nitrate and other drugs to expand the coronary arteries and improve the blood supply, and stent implantation if necessary, to improve the heart’s reperfusion. Usually, premature beats will be reduced when coronary artery disease is improved. When coronary heart disease to improve the blood supply still appear frequent premature beats, such as atrial pre-systole, ventricular pre-systole, you can follow the doctor’s instructions to choose anti-arrhythmic drugs for treatment, such as propafenone, amiodarone and so on. Coronary artery disease patients after the occurrence of premature beats, it is recommended to consult the cardiovascular internal medicine in a timely manner, after the doctor comprehensive assessment of the condition, the choice of drugs for treatment.