Sciatica has more causes, such as lumbar disc herniation and other lumbar spine diseases, pyriformis syndrome, sciatic neuritis, etc., mostly belongs to neuropathy, and methylcobalamin belongs to nutritive nerve drugs, so sciatica can take methylcobalamin. Lumbar disc herniation, lumbar osteophytes, spinal stenosis and other lumbar spine diseases, the lesion will cause compression of the nerve root, which in turn causes pain in the sciatic nerve innervated by the sciatic nerve, and pear-shaped muscle syndrome is caused by trauma to the pear-shaped muscle, adhesion and other injuries to the sciatic nerve, and the sciatic neuritis itself is a nerve lesion. Methylcobalamin belongs to the endogenous vitamin B12, which can promote nerve transmission, lecithin synthesis and the formation of nerve myelin sheaths, which has the effect of nourishing the nerves and promotes the repair of the nerves. Therefore, in the absence of drug allergies, sciatica can usually take methylcobalamin. The use of methylcobalamin can partly be allergic reactions such as skin rashes and itching, but also herpes in the mouth and tongue, scabbing of the lips, congestion of the eyelid membranes, as well as gastrointestinal reactions such as nausea, vomiting, diarrhea and other gastrointestinal reactions. Methylcobalamin is contraindicated in people with a history of hypersensitivity to any of the ingredients contained in it. It is recommended that sciatica go to the hospital before treatment to clarify the specific condition, the drug needs to be used under the guidance of a professional physician.