What is lower extremity atherosclerosis occlusive disease? Lower extremity atherosclerosis-occlusive disease is a narrowing or occlusion of the arteries due to atherosclerosis of the lower extremities, which affects the blood supply to the lower extremities. What are the risks of lower extremity atherosclerosis? In mild cases, the disease may affect the mobility of the affected limb, but in severe cases, it may cause severe resting pain, ulcers or gangrene, and even forced amputation. How to treat lower extremity atherosclerosis? Pharmacological treatment mainly includes the use of vasoactive drugs, anti-platelet drugs, statin lipid-lowering drugs, together with walking exercises, smoking cessation and other risk factors control. These treatments are primarily indicated for mild, early-stage atherosclerotic occlusive disease. Minimally invasive endoluminal treatment, using balloons and stents to dilate narrowed or occluded lesions. This treatment is primarily indicated for short segments of stenotic or occlusive disease. Reconstructive vascular surgery, which uses materials such as autologous veins or artificial blood vessels to perform vascular bypass surgery, is primarily indicated for long segments of stenotic or occlusive disease. Stem cell transplantation or revascularization surgery combined with endoluminal minimally invasive treatment is mainly applicable to multiple-segment atherosclerotic occlusive disease. Therefore, patients with lower extremity atherosclerotic occlusive disease should undergo systematic and standardized treatment under the guidance of physicians to effectively improve their quality of life.