Atherosclerosis-occlusive disease (ASO) is a common complication of atherosclerosis, and is the most common peripheral vascular disease in middle-aged and elderly people, due to the continuous expansion of atherosclerotic plaques and the formation of secondary thrombosis, causing the narrowing or even occlusion of the arterial lumen, resulting in chronic or acute ischemic symptoms in the affected limbs, with the typical symptoms of intermittent claudication, accompanied by limb coldness, low skin temperature, numbness, soreness, weakness, tingling, dorsal foot artery weakening, etc, The typical symptoms are intermittent claudication, accompanied by coldness, low skin temperature, numbness, soreness, weakness, tingling, weakening of the dorsalis pedis artery, can be complicated by hyperlipidemia, hyperglycemia, gout, etc., followed by pale, yellow or purple skin, dry skin, desquamation, sweat hair loss, toe (finger) nail deformation and other dystrophic changes, severe ulceration, infection or gangrene, severe pain, late more secondary thrombosis, rapid development of high limb extensive gangrene and life-threatening. In recent years, with the continuous improvement of people’s living standards, unreasonable dietary structure and aging of the population, the incidence of ASO has been on the rise, becoming one of the major diseases that endanger the lives of middle-aged and elderly people. For the treatment of this disease, Western medicine now mostly adopts surgical treatment such as endarterectomy, autologous vein grafting and artificial vessel grafting, which has saved the limbs of many patients with severe ischemia and become a new discipline that is currently competing for development. However, surgical treatment of atherosclerotic occlusive disease has great limitations, the patency rate of vascular diversion far from the groin is not satisfactory, due to the multi-origin of atherosclerosis etiology, the complexity of pathological changes, most patients with atherosclerotic occlusive disease after surgical treatment, the 5-year patency rate is less than 50%. It can be seen that there are great limitations in the surgical treatment of vascular lesions, and the long-term patency rate of reconstructed vessels in the lower extremities is still a difficult problem for vascular surgery. Atherosclerotic occlusive disease is a disease in which atherosclerotic lesions involve the peripheral arteries and lead to chronic occlusion. It is a part of systemic atherosclerosis. Its etiology and pathogenesis have not been fully elucidated so far. At present, it is believed that its occurrence is related to various factors such as hypertension, hyperlipidemia, high body weight and obesity, hyperglycemia, and smoking. The dyslipidemia (elevated plasma total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), apolipoprotein-B (apo-B) and decreased high-density lipoprotein (HDL)) and increased permeability caused by damage to the endothelial cells of the arterial vasculature, cause lipids to migrate into the arterial intima, and the migrated lipids trigger monocytes in the blood and smooth muscle cells in the arterial intima to enter the intima. Smooth muscle cells enter the intima, engulf the lipids and form foam cells and undergo necrosis and disintegration, stimulating the proliferation of intimal fibrous tissue, leading to the formation of atherosclerotic plaques and intimal thickening. With the increase of atherosclerotic plaque and the secondary bleeding and thrombosis at the plaque, it gradually leads to the narrowing and occlusion of the arterial lumen, thus causing the clinical manifestation of ischemia in the affected limb. According to Chinese medicine, this disease belongs to the category of “deglutition”. The mechanism of its occurrence is due to the patient’s advanced age, weakness of qi, failure of qi mechanism, stagnation of meridians, inaccessibility of veins, deficiency of evil, interconnection of evil and stasis, heat from stasis for a long time, and decay of flesh from heat. The cause of arteriosclerosis and occlusive disease is the deficiency of qi in old age, the inability to move, the stagnation of the meridians, and the heat. The use of endarterectomy, autologous vein grafting or artificial vascular grafting surgery, anticoagulation and viscosity lowering treatment is one of the effective methods for this disease, which has relieved some patients of their pain and preserved their bodies, but due to the high incidence of reocclusion after surgery, it seriously affects the patient’s outcome. In the formula of detoxifying and resolving blood stasis, we use rhubarb, Huanglian, Erhua, Gecko and Dilong to clear heat and cool the blood, dispel blood stasis and detoxify the blood, and open the meridians and activate the channels; we use leech, whole worm, centipede and Shanjia to break blood and expel blood stasis, eliminate swelling and disperse nodules, open the channels and relieve pain, and according to modern pharmacological research it has the effect of lowering blood viscosity, lowering blood lipids and cholesterol. According to modern pharmacological research, it has the effect of lowering blood viscosity, blood fat and cholesterol. The combination of all the drugs together can clear heat and activate blood circulation, resolve blood stasis, promote circulation, regulate qi and relieve pain. It is very effective in treating this disease and preventing re-clogging after surgery.