Mycoplasma and Chlamydia infections are mostly transmitted through sexual contact and are sexually transmitted diseases, which are clinically known as non-gonococcal urethritis after infection. The common mycoplasma infections are Mycoplasma solium, Mycoplasma humanum and Mycoplasma genitalium. The common chlamydia is Chlamydia trachomatis, the infection occurs when both partners can develop at the same time, can be accompanied by thin urethral discharge, with frequent urination, urinary urgency, urethral burning, or urethral orifice redness, pain and other discomfort. It is recommended that both partners go to the hospital for examination, and the examination can be done by taking the discharge for culture or smear examination, and if the smear can find inclusion bodies, the diagnosis can be confirmed. It is also necessary to treat both partners at the same time. It is recommended to take oral azithromycin for one week continuously. The use of antibiotics for women during pregnancy should be in accordance with medical advice. Doxycycline treatment is contraindicated and sexual contact should be avoided during treatment.