2015 June UMDF (United mitochondrial disease foundation) recommends a cocktail of regimens for mitochondrial disease, with specific dosing regimens: First-line recommendations: coenzyme Q10:5-15 mg/kg/day; levocanidine: starting dose 30 mg/kg/day, maximum dose 100 mg/kg/day; vitamin B2:100-400 mg/day. Second-line recommendations: acetyl levocanidine: 250-1000 mg/day; vitamin B1:500-1000 mg/day; vitamin B3:50-100 mg/day; vitamin E:200-400 IU; 1-3 times/day; vitamin C:100-500 mg; 1-3 times/day; lipoic acid: 60-200 mg; 3 times/day; selenium: 25-50 micrograms/day; beta-carotene: 10,000 IU every other day or daily; biotin: 2.5-10 mg/day; folic acid: 1-10 mg/day; vitamin K3: 5-30 mg/day; calcium, magnesium, and phosphorus as appropriate; succinic acid: 6 mg/day; creatine: 5 mg twice a day, uridine, citric acid, and prednisone as appropriate. This is the recommendation for the intermittent or relatively stable period, but it can be seen from this that most of the medications are still closely related to energy supply. Some patients are also concerned about so many drugs, do they really have to swallow them by the handful every day? Since patients with mitochondrial disease are very often complicated by abnormal gastrointestinal function, or even unable to eat at all during disease flare-ups. In the United States, such patients provide their own electronic pumps, and these drugs are available not only in tablet form, but also in liquid form. Therefore, the body’s needs can be replenished through the pump at regular intervals. Despite the recommendations, our focus will be different for different types of mitochondrial diseases, depending on the genetic test results and the patient’s specific situation. The analysis is specific to each case.