The onset of mitochondrial disease is related to acidosis in the body, which is present in almost all patients. The first step in preventing attacks is to pay attention to the timing and type of diet to prevent acidosis. First of all, do not fast for a long time, because hunger can lead to acidosis, so eat many meals a day, have a pastry or a glass of milk at 10:30 a.m., 3:30 p.m. and at night before going to bed. Be careful to keep your diet in the state of cold and diarrhea. The diet should be given alkaline foods. The acidity and alkalinity of food are related to the kinds of inorganic salts within the food. Metal ions such as potassium, sodium, calcium and magnesium are alkaline in the human body as oxides, and foods containing more of these metal ions are alkaline foods, mostly non-meat foods, including beans and soy products, vegetables, fruits, coarse grains and most fish. Grapes, wine, tea and kelp are strongly alkaline foods. Non-metallic elements such as phosphorus, sulfur and chloride ions generate acid roots with anions after oxidation in the body. Foods containing many of these non-metallic elements are acidic foods, mostly meat foods. It is recommended to develop your own special recipes according to your personal taste characteristics. Mitochondrial disease in general rapid activity can increase the number of mitochondria in the muscle, do not be in a state of hunger strenuous activity and brain, that aggravates acidosis. Activity should not be fasting, it is better to be active shortly after a meal, and timely energy supplementation during activity to increase supplemental arginine. Other metabolic muscle diseases also require diet and activity regulation.