Multidrug-Resistant Organism (MDRO) refers to bacteria that are resistant to three or more classes of antimicrobial drugs in clinical use at the same time. Common multi-drug resistant organisms include methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), ultra broad-spectrum β-lactamase-producing (ESBLs) bacteria, carbapenem-resistant Enterobacteriaceae (CRE), carbapenem-resistant Acinetobacter baumannii (CR-AB), multi-drug resistant/pan-resistant Pseudomonas aeruginosa (MDR/PDR PA) and multi-drug resistant Mycobacterium tuberculosis. In recent years, due to the misuse of antibiotics, the popularity of various invasive treatment and catheterization techniques, and the increase of intensive care units, multi-drug resistant bacteria have become important pathogens of hospital infections, and the main types of infections include urinary tract infections, surgical site infections, hospital-acquired pneumonia, catheter-related bloodstream infections, and intensive care unit infections, which are difficult to treat. Drug-resistant bacteria hospital infection prevention and control, is a difficult problem in front of Chinese and Western medicine clinical workers and hospital infection managers, I believe that as a clinical medical workers must do the following points: a. Strengthen the management of key patient groups. As multi-drug resistant bacteria occur in intensive care units (ICU), surgical wards, hematology wards, respiratory wards, neurology wards, burn wards, infection wards and other wards, patients in these wards should understand their previous antibacterial drug use, ask detailed questions about their previous basic medical history, understand their overall physical condition and immune function, especially those who have received broad-spectrum antibacterial drugs in the past. In particular, patients who have received poor treatment with broad-spectrum antibacterial drugs, patients with various indwelling tubes and patients with immunosuppressive drugs should be given priority attention. The training of medical staff should be strengthened, including education on hospital infection prevention and control, risk factors for multi-drug resistant bacterial infections, epidemiology, and prevention and control measures. Second, strict implementation of isolation and treatment and disinfection norms. For patients with confirmed or highly suspected multi-drug resistant bacterial infections or colonized patients, contact isolation measures should be implemented on the basis of standard precautions to prevent the spread of multi-drug resistant bacteria, . It is not advisable to place patients with multi-drug resistant bacteria infection or colonization in the same room with patients who have various tubes, open wounds or immunocompromised patients, and bedside isolation should be performed when there is no condition for single room isolation. Medical and nursing staff should place patients with suspected or confirmed multi-drug resistant bacterial infections at the end of room visits and nursing operations. When contacting the wounds, blood, body fluids and excretion drainage fluid of patients with multi-drug resistant bacteria infection, they should wear gloves and isolation clothes, and after finishing the diagnosis and care operation, they should take off the gloves and clothes in time and perform hand hygiene. Medical personnel in the implementation of various invasive operations, should strictly implement the aseptic technique operation and standard operating procedures to avoid contamination. Wipe and disinfect the surfaces of objects frequently touched by medical personnel and patients (such as the panels or knob surfaces of medical devices such as cardiac monitors, microinfusion pumps, ventilators, stethoscopes, rails and bedside tables, door handles) using disinfectants. When contaminated by patients’ blood and body fluids should be disinfected immediately. Third, pay attention to the role of Chinese medicine in improving the infected person’s own immune function. Chinese medicine believes that multi-drug resistant bacteria belong to “wind and temperature, wet and temperature”, and their pathogenesis must be based on the premise that the body’s positive qi is insufficient, which is what the “Nei Jing” says: “If positive qi exists within, evil cannot dry up”, “Where evil comes together, its qi must be deficient. “Therefore, the treatment of multi-drug resistant bacterial infection must carry out the concept of supporting positive qi from the beginning to the end. The effective prescriptions for the treatment of multi-drug-resistant bacterial infections in Chinese medicine are: Danggui Liuhuang Tang, Astragalus Wenbei Tang, Astragalus Qingying Tang, Lijun Shibu Tang, etc. Fourth, the rational use of antibacterial drugs. Effectively implement the graded management of antibacterial drugs, correctly and reasonably implement individualized antibacterial drug administration programs, reasonably select antibacterial drugs according to the results of clinical microbiological testing, and avoid the occurrence of bacterial resistance due to improper use of antibacterial drugs. Hospitals should establish and improve the monitoring system for multi-drug resistant bacteria. Strengthen the testing capacity of microbiology laboratories, provide and report laboratory test results in a timely manner, report changes in the detection of multi-drug resistant bacteria and infection trends to the management and relevant clinical departments, and regularly publish common clinical isolates of bacterial strains and their drug sensitivity.