Surgery is an important treatment for brain metastases. For single, large, symptomatic metastatic lesions, surgical resection of metastatic single lesions in the brain combined with whole brain radiotherapy can increase the survival time of patients than radiotherapy alone. Even with multiple intracranial brain metastases, some patients suitable for surgery can improve their quality of life and prolong survival with tumor resection. However, for patients with brain metastases, surgical resection of metastatic brain lesions is only part of the overall tumor treatment. After surgical resection of metastatic brain lesions, follow-up comprehensive treatment is needed to better prolong survival time. Ms. Du, who is almost 60 years old, had her left breast tumor removed 3 years ago and was diagnosed as “breast cancer” after surgery and underwent chemotherapy, but she could not remember the specific pathological results of the breast tumor and the drugs used in chemotherapy. Recently, a month ago, she had a headache and blurred vision, and a large tumor in the right frontal lobe was detected by MRI. After the tumor was removed, Ms. Du’s headache was relieved and she was discharged from the hospital in less than a week without any sequelae. For this kind of patients after metastasis surgery, because the edema in the brain has not completely subsided before the surgery, the patient may need to pass the peak edema period through dehydration and other treatments in the short term after the surgery, and the sutures of the incision need to be removed if the incision has not been removed, and functional rehabilitation is also needed if the patient has dysfunction in body movement and speech. If there are multiple tumors in the brain that have not been completely removed, or if the tumor is not completely removed, radiotherapy is also needed in the brain. With the control of local tumor in the brain, the patient should also combine the primary tumor lesions and metastatic lesions in other parts of the body, and select systemic targeted or chemotherapeutic drugs to control the growth of tumor cells in other parts of the body through the pathological and molecular diagnosis results after brain surgery. Only with this multi-pronged approach, it is possible to maximize the survival time and improve the quality of life.