Vulvar squamous epithelial hyperplasia, known in the medical field as proliferative dystrophy, is mainly manifested by vulvar pruritus, which is a vulvar disease with benign proliferation of squamous epithelial cells as the main manifestation. The etiology of squamous epithelial cell production and appearance is currently unknown. The disease is seen clinically mostly in middle-aged women before the age of 50, and data show that it can be more common in older postmenopausal women reported abroad. The medical analysis may be related to itchy vulva due to moist vulva and long-term stimulation of female vaginal secretions. The main symptom of the disease is itching of the vulva, which is much more severe than sclerosing moss and is usually unbearable for the patient to scratch. Although the itching can be temporarily relieved, scratching of different degrees will aggravate the lesions and make the itching more intense, as a result, the more you scratch, the more itchy you are, forming a vicious circle over time. From the appearance of the disease, the lesions are mainly on the labia majora, the interlabial sulcus, the clitoral foreskin and the posterior union of the labia. The lesions can be isolated, focal or multiple symmetrical. Early lesions are dark red or pink in color, with white areas of hyperkeratosis. In advanced stages, the skin may appear thickened, with increased pigmentation and a distinctive skin texture, leading to mossy changes. The disease may coexist with vulvar invasive carcinoma. The diagnosis can be confirmed by pathological examination. Usual treatment: 1. General treatment: In daily life, patients should keep the vulva clean and dry, prohibit the use of irritating drugs or alkaline soap and other cleaning products to clean the vulva skin, avoid wearing impermeable chemical fiber underwear, and stay away from spicy and allergic seafood. For patients with severe itching symptoms, especially at night, sedative, sleeping and anti-allergy drugs can be added. 2.Medication: Local application of corticosteroid medication is usually recommended to control itching symptoms. Common medications such as fluphenazine ointment or tretinoin ointment. Because long-term use of steroid drugs can lead to local skin atrophy, so when the itching is relieved should be stopped under the guidance of a doctor, and replaced by hydrocortisone ointment and other maintenance to continue treatment. Most patients are treated effectively, but need to adhere to long-term medication. 3.Physical therapy: such as focused ultrasound therapy, CO2 laser, helium-neon laser, etc. 4.Surgical treatment: The malignancy rate of the disease is relatively low in clinical practice, and there is still a possibility of long-term recurrence after surgery, so surgical treatment is generally not used. Surgical treatment is only used when repeated drug or physical therapy is ineffective, or when the local lesions show atypical hyperplasia and have the possibility of malignant transformation.