Vulvar squamous epithelial warty growths are commonly seen in acromegaly, which is also known as acromegaly, genital warts, acromegaly, and venereal warts. It is a type of epidermodysplasia caused by infection with the human papilloma virus (HPV). They are found on the external genitalia, anus, prepuce, perineum, clitoris, cervix and vagina, as well as the urethra, urethra, rectum, oral cavity, nipples, umbilicus, groin, and between the toes, bladder and ureter. The pathological examination reveals concave hollow cells, which are the characteristic pathological changes of acromegaly and have important diagnostic value; followed by pathological changes such as capillary hyperplasia of dermal papillae, basal cell hyperplasia, spiny cell hyperplasia, keratosis imperfecta and dyskeratosis. The disease is generally not difficult to diagnose based on the characteristics of the rash, site of onset, and development combined with the history of exposure that may be inquired about. Subclinical infections can be isolated or coexist with typical lesions and can be diagnosed with a white acetate test or toluidine blue test. For latent infections, in situ hybridization or polymerase chain reaction (PCR) can be used to confirm.